Description
Recombinant human HTRA1 (161-379) protein was expressed in E Coli cells using an N-terminal His-tag. The protein accession number is NM_002775.
HTRA1 is a serine protease. HTRA1 targets a variety of proteins (1 & 2), including fibronectin (induce synovial cells to up-regulate MMP1 and MMP3 production), proteoglycans (release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space), IGF-binding proteins (regulates the availability of insulin-like growth factors) and TSC2 (leads to the activation of TSC2 downstream targets). HTRA1 relates to age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss (3)